Efficacy of epigallocatechin-3-gallate and Amla (Emblica officinalis) extract for the treatment of diabetic-uremic patients

J Med Food. Jul-Aug 2011;14(7-8):718-23. doi: 10.1089/jmf.2010.1195. Epub 2011 Jun 1.

Abstract

Uremic patients with diabetes suffer from high levels of oxidative stress due to regular hemodialysis therapy (neutrophil activation induced by hemo-incompatibility between the hemodialyser and blood) and complications associated with diabetes. Several plasma biomarkers were screened in 13 uremic diabetic patients after receiving the mixture of (-)-epigallocatechin gallate (EGCG), a major component of green tea extract, and Amla extract (AE), from Emblica officinalis, the Indian gooseberry, for 3 months. We found that oral administration of a 1:1 mixture of EGCG and AE for 3 months significantly improved antioxidant defense as well as diabetic and atherogenic indices in uremic patients with diabetes. Furthermore, no significant changes in hepatic function, renal function, or inflammatory responses were observed. These results suggest that a 1:1 combination of EGCG and AE is a safe and effective treatment for uremic patients with diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Catechin / administration & dosage
  • Catechin / analogs & derivatives*
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus / physiopathology
  • Female
  • Humans
  • Kidney / metabolism
  • Kidney / physiopathology
  • Liver Function Tests
  • Male
  • Middle Aged
  • Oxidative Stress / drug effects
  • Phyllanthus emblica / chemistry*
  • Phytotherapy
  • Plant Extracts / administration & dosage*
  • Uremia / drug therapy*
  • Uremia / metabolism
  • Uremia / physiopathology

Substances

  • Plant Extracts
  • Catechin
  • epigallocatechin gallate