4-Methylpyrazole as a treatment in naturally occurring ethylene glycol intoxication in cats

J Vet Emerg Crit Care (San Antonio). 2011 Jun;21(3):268-72. doi: 10.1111/j.1476-4431.2011.00638.x. Epub 2011 Apr 29.

Abstract

Objective: To describe the clinical experience and therapeutic use of fomepizole (4-methylpyrazole [4-MP]) in 3 cats with naturally occurring ethylene glycol (EG) toxicity.

Case or series summary: All cats were documented to be EG positive by an ethylene glycol test kit. This report describes the dose of 4-MP used, available clinicopathological data, and clinical progression during hospitalization. All patients survived to discharge.

New or unique information provided: IV use of 4-MP at 125 mg/kg as an initial dose and 31.25 mg/kg at 12, 24, and 36 hours is safe and effective for treatment of naturally occurring EG toxicity in cats. Increased HCO₃ concentrations were noted after IV use of 4-MP. This is the first report documenting the successful treatment of naturally occurring EG intoxication in cats with 4-MP.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Antidotes / administration & dosage*
  • Cat Diseases / chemically induced*
  • Cat Diseases / drug therapy*
  • Cats
  • Ethylene Glycol / poisoning*
  • Female
  • Fomepizole
  • Male
  • Pyrazoles / administration & dosage*
  • Treatment Outcome

Substances

  • Antidotes
  • Pyrazoles
  • Fomepizole
  • Ethylene Glycol