[Gender and health status response to long-term oxygen therapy in COPD patients]

Arch Bronconeumol. 2011 Aug;47(8):382-8. doi: 10.1016/j.arbres.2011.03.009. Epub 2011 May 31.
[Article in Spanish]

Abstract

Introduction: The association of gender with health status (HS) response to long-term oxygen therapy (LTOT) in very severe COPD is unclear. The aims of this study were: (1) to compare dyspnea perception and HS between male and female with very severe COPD at baseline and (2) to provide a prospective assessment of HS response to LTOT, according to gender.

Patients and methods: Hypoxemic COPD (n = 97, age: 65.5 ± 9.6 years, 53% males) were enrolled in a prospective longitudinal study over 12 months or until death. St. George's Respiratory Questionnaire (SGRQ) and baseline dyspnea index (BDI) were assessed.

Results: At baseline, HS impairment and dyspnea sensation were similar between genders. After 12 months of LTOT, women presented improvement in symptom (64.1 ± 20.6 versus 40.6 ± 22.9; P < 0.0001) and total SGRQ scores. Men also showed improvement in symptoms after 12 months (62.7 ± 23.3 versus 49.6 ± 22.8; P < 0.0005); however, they presented deterioration of activity, impact and total scores during the study period, with markedly decline of activity domain (68.5 ± 20.0 versus 75.9 ± 16.9; P = 0.008). BDI did not show significant difference by gender over the study period.

Conclusions: Our results show that the HS course in very severe COPD patients differs according to gender, as females show greater response longitudinally to LTOT.

Publication types

  • Comparative Study

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Aged
  • Brazil / epidemiology
  • Bronchodilator Agents / therapeutic use
  • Combined Modality Therapy
  • Comorbidity
  • Disease Progression
  • Diuretics / therapeutic use
  • Dyspnea / etiology
  • Female
  • Follow-Up Studies
  • Forced Expiratory Volume
  • Health Status*
  • Humans
  • Hypoxia / etiology
  • Male
  • Middle Aged
  • Oxygen Inhalation Therapy*
  • Prospective Studies
  • Pulmonary Disease, Chronic Obstructive / complications
  • Pulmonary Disease, Chronic Obstructive / drug therapy
  • Pulmonary Disease, Chronic Obstructive / epidemiology
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Pulmonary Disease, Chronic Obstructive / therapy*
  • Severity of Illness Index
  • Sex Factors*
  • Smoking / epidemiology
  • Surveys and Questionnaires
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Bronchodilator Agents
  • Diuretics