IGF-I and visfatin levels in retinopathy of prematurity

J Pediatr Ophthalmol Strabismus. Mar-Apr 2012;49(2):120-4. doi: 10.3928/01913913-20110531-01. Epub 2011 Jun 7.


Purpose: The authors hypothesized that circulating visfatin concentrations in preterm infants might be linked with retinopathy of prematurity (ROP)-like insulin-like growth factor I (IGF-I) levels.

Methods: The study group comprised 88 children born with a gestational age younger than 32 weeks between 2007 and 2009 who were screened and/or treated for ROP. The authors collected fetal cord blood (sample 1) and a blood sample at 4 to 6 weeks postnatal age (sample 2) for laboratory investigations.

Results: The non-ROP group had higher visfatin-1, visfatin-2, insulin-1, insulin-2, (IGF-I)-1, and (IGF-I)-2 levels than the ROP group (P < .001 for all levels). Change in visfatin was positively correlated with change in IGF-I and change in insulin (P < .001 and P < .001, respectively). Change in IGF-I was positively correlated with change in insulin (P < .001).

Conclusion: Similar to IGF-I levels, determination of visfatin levels can be a predictive marker of ROP, but more studies are needed.

MeSH terms

  • Biomarkers / blood
  • Cytokines / blood*
  • Female
  • Fetal Blood
  • Gestational Age
  • Humans
  • Immunoenzyme Techniques
  • Infant
  • Infant, Newborn
  • Infant, Very Low Birth Weight
  • Insulin / blood
  • Insulin-Like Growth Factor I / metabolism*
  • Luminescent Measurements
  • Male
  • Nicotinamide Phosphoribosyltransferase / blood*
  • Radioimmunoassay
  • Retinopathy of Prematurity / blood*


  • Biomarkers
  • Cytokines
  • Insulin
  • Insulin-Like Growth Factor I
  • Nicotinamide Phosphoribosyltransferase
  • nicotinamide phosphoribosyltransferase, human