Effects of acetazolamide on epileptic apnea in migrating partial seizures in infancy

Epilepsy Res. 2011 Sep;96(1-2):185-9. doi: 10.1016/j.eplepsyres.2011.05.007. Epub 2011 Jun 1.


We report two cases of migrating partial seizures in infancy complicated with intractable epileptic apnea with severe desaturation. Ictal electroencephalography revealed migrating foci of epileptiform discharges, which spread to bilateral temporal areas resulting in the onset of apnea. Magnetoencephalography detected dipole sources at bilateral perisylvian areas. Single photon emission tomography revealed a significant ictal change in perfusion at bilateral anterior temporal lobes in one patient. Addition of acetazolamide to the regimen resulted in complete disappearance of epileptic seizures.

Publication types

  • Case Reports

MeSH terms

  • Acetazolamide / therapeutic use*
  • Anticonvulsants / therapeutic use*
  • Apnea / complications
  • Apnea / diagnosis
  • Apnea / drug therapy*
  • Electroencephalography
  • Epilepsies, Partial / complications
  • Epilepsies, Partial / diagnosis
  • Epilepsies, Partial / drug therapy*
  • Female
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Magnetoencephalography
  • Male
  • Temporal Lobe / diagnostic imaging
  • Temporal Lobe / drug effects
  • Temporal Lobe / pathology
  • Temporal Lobe / physiopathology
  • Tomography, Emission-Computed, Single-Photon


  • Anticonvulsants
  • Acetazolamide