Time-dependent changes in the plasma amino acid concentration in diabetes mellitus

Mol Genet Metab. 2011 Aug;103(4):406-9. doi: 10.1016/j.ymgme.2011.05.002. Epub 2011 May 12.


We investigated longitudinal change in the amino acid (AA) profile in type 1 diabetes mellitus (DM) using AKITA mice, which develop DM as a result of insulin deficiency. The plasma concentrations of valine, leucine, isoleucine, as well as the total branched chain amino acids, alanine, citrulline and proline, were significantly higher in the diabetic mice. We show that the degree and timing of the changes were different among the plasma amino acid concentrations (pAAs) during the development of type 1 DM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine / blood
  • Amino Acids / blood*
  • Amino Acids, Branched-Chain / blood
  • Animals
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / metabolism*
  • Insulin / blood
  • Isoleucine / metabolism
  • Leucine / blood
  • Longitudinal Studies
  • Mice
  • Mice, Inbred Strains


  • Amino Acids
  • Amino Acids, Branched-Chain
  • Blood Glucose
  • Insulin
  • Isoleucine
  • Leucine
  • Alanine