Efficacy of an MFGM-enriched complementary food in diarrhea, anemia, and micronutrient status in infants

J Pediatr Gastroenterol Nutr. 2011 Nov;53(5):561-8. doi: 10.1097/MPG.0b013e318225cdaf.


Objective: The aim of the present study was to evaluate the efficacy of a milkfat globule membrane (MFGM)-enriched protein fraction in a complementary food, on diarrhea, anemia, and micronutrient status.

Subjects and methods: A randomized, double-blind controlled design to study 550 infants, 6 to 11 months old, who received daily for 6 months a complementary food (40 g/day) with the protein source being either the MFGM protein fraction or skim milk proteins (control). Health and nutritional status of infants were examined monthly in the outpatient clinic; product intake, food patterns, and diarrhea morbidity were assessed by home visits twice per week. Hemoglobin and micronutrient status were measured at 0 and 6 months of intervention. Results are presented as the entire group and as 6 to 8 and 9 to 11 months subgroups.

Results: A total of 499 infants completed the study. Global prevalence of diarrhea was 3.84% and 4.37% in the MFGM group and control group, respectively (P < 0.05). Consumption of the MFGM protein fraction reduced episodes of bloody diarrhea (odds ratio 0.54; 95% confidence interval 0.31-0.93, P = 0.025) adjusting for anemia and potable water facilities as covariates. There were no differences between groups in anemia, serum ferritin, zinc, or folate.

Conclusions: Addition of an MFGM-enriched protein fraction to complementary food had beneficial effects on diarrhea in infants and may thus help to improve the health of vulnerable populations.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Anemia, Iron-Deficiency / drug therapy
  • Anemia, Iron-Deficiency / epidemiology*
  • Animals
  • Diarrhea / drug therapy
  • Diarrhea / epidemiology*
  • Double-Blind Method
  • Drinking Water
  • Energy Intake
  • Feces / microbiology
  • Female
  • Ferritins / blood
  • Folic Acid / blood
  • Food, Fortified*
  • Humans
  • Infant
  • Infant Nutritional Physiological Phenomena*
  • Iron, Dietary / administration & dosage
  • Logistic Models
  • Longitudinal Studies
  • Male
  • Micronutrients / administration & dosage*
  • Milk
  • Milk Proteins / administration & dosage*
  • Multivariate Analysis
  • Nutritional Status
  • Peru / epidemiology
  • Whey Proteins
  • Zinc / blood
  • Zinc / deficiency


  • Drinking Water
  • Iron, Dietary
  • Micronutrients
  • Milk Proteins
  • Whey Proteins
  • Ferritins
  • Folic Acid
  • Zinc