Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate

Nature. 2011 Jun 2;474(7349):49-53. doi: 10.1038/nature10109.

Abstract

Type 1 pili are the archetypal representative of a widespread class of adhesive multisubunit fibres in Gram-negative bacteria. During pilus assembly, subunits dock as chaperone-bound complexes to an usher, which catalyses their polymerization and mediates pilus translocation across the outer membrane. Here we report the crystal structure of the full-length FimD usher bound to the FimC-FimH chaperone-adhesin complex and that of the unbound form of the FimD translocation domain. The FimD-FimC-FimH structure shows FimH inserted inside the FimD 24-stranded β-barrel translocation channel. FimC-FimH is held in place through interactions with the two carboxy-terminal periplasmic domains of FimD, a binding mode confirmed in solution by electron paramagnetic resonance spectroscopy. To accommodate FimH, the usher plug domain is displaced from the barrel lumen to the periplasm, concomitant with a marked conformational change in the β-barrel. The amino-terminal domain of FimD is observed in an ideal position to catalyse incorporation of a newly recruited chaperone-subunit complex. The FimD-FimC-FimH structure provides unique insights into the pilus subunit incorporation cycle, and captures the first view of a protein transporter in the act of secreting its cognate substrate.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesins, Escherichia coli / chemistry*
  • Adhesins, Escherichia coli / metabolism
  • Crystallization
  • Escherichia coli Proteins / chemistry*
  • Escherichia coli Proteins / metabolism
  • Fimbriae Proteins / chemistry*
  • Fimbriae Proteins / metabolism
  • Models, Molecular*
  • Protein Binding
  • Protein Structure, Quaternary

Substances

  • Adhesins, Escherichia coli
  • Escherichia coli Proteins
  • fimC protein, E coli
  • fimD protein, E coli
  • fimH protein, E coli
  • Fimbriae Proteins

Associated data

  • PDB/3OHN
  • PDB/3RFZ