The role of alpha 1-adrenoceptor subtypes in the regulation of arterial blood pressure

Eur J Pharmacol. 1990 May 16;180(2-3):381-6. doi: 10.1016/0014-2999(90)90327-3.

Abstract

The effect of chlorethylclonidine on alpha 1-adrenoceptor subtypes and arterial blood pressure has been evaluated. Chlorethylclonidine significantly reduced the alpha 1-adrenoceptor population. Chlorethylclonidine treatment had no significant effect on resting systemic arterial blood pressure or heart rate and shifted the phenylephrine pressor dose-response curve only 2.4-fold to the right. These data suggest that only one of the alpha 1-adrenoceptor subtypes plays a major role in the regulation of arterial blood pressure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anesthesia
  • Animals
  • Aorta, Thoracic / drug effects
  • Binding Sites
  • Blood Pressure / drug effects*
  • Clonidine / analogs & derivatives
  • Clonidine / pharmacology
  • Dose-Response Relationship, Drug
  • Heart Rate / drug effects
  • In Vitro Techniques
  • Male
  • Phenylephrine / pharmacology
  • Prazosin / metabolism
  • Rats
  • Rats, Inbred Strains
  • Receptors, Adrenergic, alpha / drug effects*
  • Receptors, Adrenergic, alpha / physiology

Substances

  • Receptors, Adrenergic, alpha
  • Phenylephrine
  • chlorethylclonidine
  • Clonidine
  • Prazosin