Intraductal papillomas of the breast: diagnosis and management of 151 patients

Breast. 2011 Dec;20(6):501-4. doi: 10.1016/j.breast.2011.05.004. Epub 2011 Jun 2.


Introduction: The assessment of papillary lesions continues to be a challenging area in breast radiology and pathology. The management of intraductal papillomas without atypia of the breast remains controversial. The purpose of the present study was to determine diagnostic accuracy of radiographical diagnosis, core biopsy, and surgical excision in papillary breast lesions.

Material and methods: By using files from 1995 to 2010, 151 cases of intraductal papilloma with or without atypia were identified. Patients were stratified as follows: core biopsy followed by surgical excision (n = 61), core biopsy alone (n = 19), and surgical excision alone (n = 71).

Results: The upstage rate of intraductal papillomas without atypia on core biopsy to atypia or malignancy on excision was 8.9%. Excision specimens revealed intraductal papillomas without atypia in 68 out of 71 cases, and atypical papillomas in 3 cases.

Conclusion: Our findings suggest that radiographic and histopathological diagnosis of intraductal papillomas show high accuracy and good concordance. In cases where the radiographic diagnosis reveals suspicious lesions core biopsy represents the first choice.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy, Needle
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery*
  • Decision Making
  • Female
  • Germany
  • Humans
  • Mammography
  • Middle Aged
  • Papilloma, Intraductal / diagnosis*
  • Papilloma, Intraductal / pathology
  • Papilloma, Intraductal / surgery*
  • Predictive Value of Tests
  • Retrospective Studies
  • Sensitivity and Specificity