The influence of Flutter®VRP1 components on mucus transport of patients with bronchiectasis

Respir Med. 2011 Sep;105(9):1316-21. doi: 10.1016/j.rmed.2011.04.017.


Background: The Flutter(®)VRP1 combines high frequency oscillation and positive expiratory pressure (PEP).

Objective: To separately evaluate the effect of the Flutter(®)VRP1 components (high frequency oscillation and PEP) on mucus transportability in patients with bronchiectasis.

Methods: Eighteen patients with bronchiectasis received sessions with the Flutter(®)VRP1 or PEP for 30 min daily in a randomized, crossover study. The treatment duration was four weeks with one of the therapies, one week of a "wash-out" period and followed by four more weeks with the other treatment. Weekly secretion samples were collected and evaluated for mucociliary relative transport velocity (RTV), displacement in a simulated cough machine (SCM) and contact angle measurement (CAM). For the proposed comparisons, a linear regression model was used with mixed effects with a significance level of 5%.

Results: The Flutter(®)VRP1 treatment resulted in greater displacement in SCM and lower CAM when comparing results from the first (9.6 ± 3.4 cm and 29.4 ± 5.7°, respectively) and fourth weeks of treatment (12.44 ± 10.5 cm and 23.28 ± 6.2°, respectively; p < 0.05). There was no significant difference in the RTV between the treatment weeks for either the Flutter(®)VRP1 or PEP.

Conclusion: The use of the Flutter(®)VRP1 for four weeks is capable of altering the respiratory secretion transport properties, and this alteration is related to the high frequency oscillation component.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchiectasis / physiopathology*
  • Bronchiectasis / therapy
  • Chest Wall Oscillation / instrumentation*
  • Chest Wall Oscillation / methods
  • Cross-Over Studies
  • Equipment Design
  • Female
  • Humans
  • Linear Models
  • Lung / physiopathology*
  • Male
  • Middle Aged
  • Mucociliary Clearance*
  • Mucus
  • Positive-Pressure Respiration / instrumentation
  • Positive-Pressure Respiration / methods
  • Treatment Outcome
  • Vibration*