Steroid hormone hypersensitivity: clinical presentation and management

Fertil Steril. 2011 Jun 30;95(8):2571-3. doi: 10.1016/j.fertnstert.2011.05.025. Epub 2011 Jun 8.

Abstract

Hypersensitivity to estrogens and progestogens is often undiagnosed. The condition has many manifestations, including premenstrual syndrome, dysmenorrhea, and impaired fertility. Diagnosis is confirmed by skin testing for inflammatory responses to small doses of the hormone, and desensitization with small doses of the hormone is the most appropriate form of management.

MeSH terms

  • Animals
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / etiology
  • Autoimmune Diseases / therapy
  • Dermatitis
  • Desensitization, Immunologic*
  • Dietary Supplements*
  • Dysmenorrhea / diagnosis
  • Dysmenorrhea / etiology
  • Dysmenorrhea / therapy
  • Estrogens / adverse effects*
  • Estrogens / therapeutic use
  • Female
  • Humans
  • Hypersensitivity / diagnosis*
  • Hypersensitivity / etiology
  • Hypersensitivity / therapy*
  • Infertility / diagnosis
  • Infertility / etiology
  • Infertility / therapy
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Complications / diagnosis
  • Pregnancy Complications / etiology
  • Pregnancy Complications / therapy
  • Premenstrual Syndrome / diagnosis
  • Premenstrual Syndrome / etiology
  • Premenstrual Syndrome / therapy
  • Progesterone / adverse effects*
  • Progesterone / therapeutic use
  • Skin Tests*
  • Treatment Outcome

Substances

  • Estrogens
  • Progesterone

Supplementary concepts

  • Autoimmune progesterone dermatitis