Prospective study on central venous line associated bloodstream infections

Arch Dis Child. 2011 Sep;96(9):827-31. doi: 10.1136/adc.2010.208595. Epub 2011 Jun 2.


Objective: To prospectively assess the incidence rates and characteristics of central venous line associated bloodstream infections (CLABSI) in one institution.

Methods: All patients with indwelling central venous catheters (CVC) between 1 April 2008 and 31 March 2009 were enrolled. The medical records of patients were reviewed and information on relevant characteristics entered into a standardised questionnaire. Central laboratory records were regularly checked for positive blood cultures in study patients.

Results: There were 209 CVC for a total of 14752 CVC days in 152 patients (88 males, 58%) including neonates and patients with surgical conditions and haemato-oncological and other underlying diseases. Median age at CVC insertion was 3 months (IQR 0-56 months). Fourteen CLABSI occurred in 13 patients. Overall CLABSI incidence (per 1000 CVC days) was 0.95 (9.71 for silastic percutaneous CVC, 7.65 for other CVC, 1.97 for Broviac, 0.18 for Port-a-cath). CVC remained in place for ≤ 14 days in 109 (52%) instances, 15-90 days in 45 (22%) instances and > 90 days in 55 (26%) instances. The incidence of CLABSI in these three categories was 3.36, 4.36 and 0.47, respectively. Predominating cultured organisms were coagulase-negative staphylococci (N=3), S. aureus (N=3), and Enterococcus spp. (N=3).

Conclusions: CLABSI incidence varied by type of catheter and type of patient, with the highest risk in neonates (with silastic percutaneous CVC) and by far the lowest risk for Port-a-cath CVC. Prophylactic measures to reduce CLABSI should be tailored to individual types of catheters and patient characteristics.

MeSH terms

  • Bacteremia / etiology*
  • Candidemia / etiology
  • Catheter-Related Infections / etiology*
  • Catheterization, Central Venous / adverse effects*
  • Catheterization, Central Venous / instrumentation
  • Catheterization, Central Venous / methods
  • Child, Preschool
  • Cross Infection / etiology*
  • Epidemiologic Methods
  • Equipment Contamination
  • Female
  • Hospital Units
  • Humans
  • Infant
  • Infant, Newborn
  • Male