Cytochrome c oxidases: polypeptide composition, role of subunits, and location of active metal centers

Arch Biochem Biophys. 1990 Aug 1;280(2):242-51. doi: 10.1016/0003-9861(90)90326-t.

Abstract

The general structure of the enzyme, its polypeptide composition, and a proposal for a rational nomenclature are discussed. The mitochondrially coded and bacterial cytochrome c oxidase subunits have been analyzed with more attention focused on elucidating the number of metals present in the enzyme and the ligands available for their coordination. The picture of a 2 Cu/2 Fe enzyme has been compared with that of a 3 Cu/2 Fe enzyme and a new model is proposed for the location of the metal centers in the enzyme.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Biological Evolution
  • Cattle
  • Electron Transport Complex IV / analysis*
  • Macromolecular Substances
  • Molecular Sequence Data
  • Peptides / analysis*
  • Terminology as Topic

Substances

  • Macromolecular Substances
  • Peptides
  • Electron Transport Complex IV