Dissecting the complexity of the nervous system by enhancer detection

Bioessays. 1990 May;12(5):199-204. doi: 10.1002/bies.950120502.

Abstract

Enhancer detectors are DNA constructs which, when introduced into a eukaryotic genome, respond to nearby genomic transcriptional regulatory elements by means of a reporter gene, revealing the expression pattern of genes in their vicinity. Recent experiments in Drosophila suggest that enhancer detection is a powerful method to identify genes that are expressed in the nervous system. Since enhancer detectors allow a rapid molecular and genetic characterization of genes in their vicinity, the method will greatly facilitate the study of neural development and behavior.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Transposable Elements
  • Drosophila melanogaster
  • Enhancer Elements, Genetic*
  • Gene Expression
  • Genetic Techniques
  • Nervous System / embryology
  • Nervous System Physiological Phenomena*

Substances

  • DNA Transposable Elements