Expression of interleukin-22 in Sjögren's syndrome: significant correlation with disease parameters

Scand J Immunol. 2011 Oct;74(4):377-82. doi: 10.1111/j.1365-3083.2011.02583.x.


Sjögren's syndrome (SS) is an autoimmune disease targeting the exocrine glands resulting in xerostomia/keratoconjunctivitis sicca. Presently, we examined the levels and clinical correlations of IL-22 in SS. Patients with SS together with normal controls were randomly selected. IL-22 was detected at significantly higher levels in sera of patients with SS. The levels of IL-22 present in sera showed statistically significant direct correlations with hyposalivation, anti-SSB, anti-SSA/SSB combined, hypergammaglobulinemia and rheumatoid factor. IL-22 showed a direct correlation with major clinical parameters. The data suggest that IL-22 plays a critical role in the development of SS, and further study is needed to examine its function in human SS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Enzyme-Linked Immunosorbent Assay
  • Exocrine Glands / immunology
  • Exocrine Glands / pathology
  • Female
  • Humans
  • Hypergammaglobulinemia / immunology
  • Interleukins / biosynthesis
  • Interleukins / blood*
  • Keratoconjunctivitis Sicca / immunology
  • Male
  • Middle Aged
  • Rheumatoid Factor / immunology
  • Sjogren's Syndrome / blood*
  • Sjogren's Syndrome / immunology
  • Xerostomia / immunology


  • Interleukins
  • Rheumatoid Factor
  • interleukin-22