The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status

Diabetes Res Clin Pract. 2011 Sep;93(3):e95-7. doi: 10.1016/j.diabres.2011.05.018. Epub 2011 Jun 8.


Aims: To explore associations between IRS-1 rs1801278 G>A polymorphism and metabolic syndrome (MS).

Methods: rs1801278 G>A was genotyped in 610 healthy Argentinian men.

Results: GA carriers had lower risk of MS (OR=0.52, P=0.045), particularly among smokers (OR=0.10, P=0.006).

Conclusions: rs1801278 GA carriers had lower risk of MS, especially among smokers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Argentina / epidemiology
  • Genotype
  • Humans
  • Insulin Receptor Substrate Proteins / genetics*
  • Insulin Resistance / genetics
  • Logistic Models
  • Male
  • Metabolic Syndrome / epidemiology*
  • Metabolic Syndrome / genetics*
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Risk Factors
  • Smoking / adverse effects*
  • Young Adult


  • IRS1 protein, human
  • Insulin Receptor Substrate Proteins