g:Profiler--a web server for functional interpretation of gene lists (2011 update)

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W307-15. doi: 10.1093/nar/gkr378. Epub 2011 Jun 6.


Functional interpretation of candidate gene lists is an essential task in modern biomedical research. Here, we present the 2011 update of g:Profiler (http://biit.cs.ut.ee/gprofiler/), a popular collection of web tools for functional analysis. g:GOSt and g:Cocoa combine comprehensive methods for interpreting gene lists, ordered lists and list collections in the context of biomedical ontologies, pathways, transcription factor and microRNA regulatory motifs and protein-protein interactions. Additional tools, namely the biomolecule ID mapping service (g:Convert), gene expression similarity searcher (g:Sorter) and gene homology searcher (g:Orth) provide numerous ways for further analysis and interpretation. In this update, we have implemented several features of interest to the community: (i) functional analysis of single nucleotide polymorphisms and other DNA polymorphisms is supported by chromosomal queries; (ii) network analysis identifies enriched protein-protein interaction modules in gene lists; (iii) functional analysis covers human disease genes; and (iv) improved statistics and filtering provide more concise results. g:Profiler is a regularly updated resource that is available for a wide range of species, including mammals, plants, fungi and insects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease / genetics
  • Gene Expression Profiling
  • Genes*
  • Genome, Human
  • Humans
  • Internet
  • Molecular Sequence Annotation
  • Multiprotein Complexes / analysis
  • Polymorphism, Single Nucleotide
  • Protein Interaction Mapping
  • Software*


  • Multiprotein Complexes