Modeling the effects of a simple immune system and immunodeficiency on the dynamics of conjointly growing tumor and normal cells

Int J Biol Sci. 2011;7(6):700-7. doi: 10.7150/ijbs.7.700. Epub 2011 Jun 1.


In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotherapeutic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerical simulations, we illustrate that the interdependency of tumor-normal cells, together with choice of drug and the nature of the immunodeficiency, leads to a variety of interesting patterns in the evolution of both the tumor and the normal cell populations.

Keywords: Aging; Immune system; Immunodeficiency; Immunotherapy; chemotherapy; normal cell dynamics; tumor cell dynamics; tumor-normal cell interactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Growth Processes*
  • Computer Simulation
  • Immunotherapy
  • Models, Biological*
  • Neoplasms / immunology
  • Neoplasms / physiopathology*
  • Neoplasms / therapy