Do complement factor H 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome?

K Poolpol; B Gadner; S Neururer; A Mellmann; H Karch; D Orth; R Würzner

doi:10.1111/j.1744-313X.2011.01017.x

Do complement factor H 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome?

Int J Immunogenet. 2011 Oct;38(5):383-7. doi: 10.1111/j.1744-313X.2011.01017.x. Epub 2011 Jun 7.

Authors

K Poolpol¹, B Gadner, S Neururer, A Mellmann, H Karch, D Orth, R Würzner

Affiliation

¹ Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Austria.

PMID: 21649859
DOI: 10.1111/j.1744-313X.2011.01017.x

Abstract

Typical haemolytic uraemic syndrome (HUS) is mainly caused by infections with enterohaemorrhagic Escherichia coli, whereas in atypical, nonbacteria-associated HUS, complement plays a dominant role. Recently, complement has also been shown to be involved in typical HUS. In this study, mostly weakly significant associations with homozygosities of complement allotype C7 M and inversely with factor H 402H were found, suggesting that 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Complement Factor H / genetics
Complement Factor H / immunology
Complement System Proteins / genetics
Escherichia coli Infections / genetics*
Escherichia coli Infections / immunology
Escherichia coli Infections / pathology
Hemolytic-Uremic Syndrome / genetics*
Hemolytic-Uremic Syndrome / immunology
Hemolytic-Uremic Syndrome / microbiology
Humans
Mutation*

Substances

CFH protein, human
Complement Factor H
Complement System Proteins