Do Complement Factor H 402Y and C7 M Allotypes Predispose to (Typical) Haemolytic Uraemic Syndrome?

Int J Immunogenet. 2011 Oct;38(5):383-7. doi: 10.1111/j.1744-313X.2011.01017.x. Epub 2011 Jun 7.

Abstract

Typical haemolytic uraemic syndrome (HUS) is mainly caused by infections with enterohaemorrhagic Escherichia coli, whereas in atypical, nonbacteria-associated HUS, complement plays a dominant role. Recently, complement has also been shown to be involved in typical HUS. In this study, mostly weakly significant associations with homozygosities of complement allotype C7 M and inversely with factor H 402H were found, suggesting that 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Complement Factor H / genetics
  • Complement Factor H / immunology
  • Complement System Proteins / genetics
  • Escherichia coli Infections / genetics*
  • Escherichia coli Infections / immunology
  • Escherichia coli Infections / pathology
  • Hemolytic-Uremic Syndrome / genetics*
  • Hemolytic-Uremic Syndrome / immunology
  • Hemolytic-Uremic Syndrome / microbiology
  • Humans
  • Mutation*

Substances

  • complement factor H, human
  • Complement Factor H
  • Complement System Proteins