Reduced Adenosine 3',5'-cyclic Monophosphate Levels in Patients With Reversible Obstructive Airways Disease

Clin Exp Pharmacol Physiol. Jan-Feb 1979;6(1):111-5. doi: 10.1111/j.1440-1681.1979.tb00013.x.

Abstract

1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of adenosine 3',5'-cyclic monophosphate (cyclic AMP) were found in pulmonary tissue obtained from patients with reversible obstructive airways disease, lending support to the beta-adrenergic theory of asthma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Airway Obstruction / metabolism*
  • Airway Obstruction / physiopathology
  • Cyclic AMP / metabolism*
  • Cyclic GMP / metabolism
  • Forced Expiratory Volume
  • Humans
  • In Vitro Techniques
  • Isoproterenol / pharmacology
  • Lung / metabolism*

Substances

  • Cyclic AMP
  • Cyclic GMP
  • Isoproterenol