Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model

J Ethnopharmacol. 2011 Sep 1;137(1):336-40. doi: 10.1016/j.jep.2011.05.029. Epub 2011 May 31.


Ethnopharmacological relevance: Chamomile is most popular used medicinal plant and extensively consumed as a tea or tisanes. Traditionally this plant was used for treatment of many ailments such as allergy disorders and inflammatory mediated diseases.

Aim of the study: We investigated the effects of anti-allergic activity of Matricaria recutita L. on mast cell mediated allergic models.

Materials and methods: The protective effect of methanol extract of Matricaria recutita against compound 48/80 induced anaphylaxis and pruritis models for acute phase of hypersensitivity reactions were carried out. The late phase hypersensitivity reactions by compound 48/80 induced mast cell degranulation and histamine release from blood along with serum nitric oxide (NO), rat peritoneal fluid nitric oxide (NO) and bronchoalveolar fluid nitric oxide (NO) levels were measured.

Results: The methanol extract of Matricaria recutita L. showed inhibitory effects on anaphylaxis induced by compound 48/80 and significant dose dependent anti-pruritis property was observed by inhibiting the mast cell degranulation. Mast cell membrane stabilization activity was also observed in compound 48/80 induced mast cell activation. Dose dependent reduction in the histamine release, along with decreased release of serum, rat peritoneal and BAL fluid nitric oxide (NO) levels were observed.

Conclusion: These results suggest that the methanol extract of Matricaria recutita showed potent anti-allergic activity by inhibition of histamine release from mast cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anaphylaxis / blood
  • Anaphylaxis / immunology
  • Anaphylaxis / prevention & control*
  • Animals
  • Anti-Allergic Agents / chemistry
  • Anti-Allergic Agents / isolation & purification
  • Anti-Allergic Agents / pharmacology*
  • Ascitic Fluid / metabolism
  • Bronchoalveolar Lavage Fluid / chemistry
  • Cell Degranulation / drug effects
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Histamine Release / drug effects
  • Hypersensitivity / blood
  • Hypersensitivity / immunology
  • Hypersensitivity / prevention & control*
  • Male
  • Mast Cells / drug effects*
  • Mast Cells / immunology
  • Mast Cells / metabolism
  • Matricaria* / chemistry
  • Methanol / chemistry
  • Mice
  • Mice, Inbred BALB C
  • Nitric Oxide / blood
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plants, Medicinal
  • Pruritus / blood
  • Pruritus / immunology
  • Pruritus / prevention & control*
  • Rats
  • Rats, Sprague-Dawley
  • Solvents / chemistry
  • p-Methoxy-N-methylphenethylamine


  • Anti-Allergic Agents
  • Plant Extracts
  • Solvents
  • Nitric Oxide
  • p-Methoxy-N-methylphenethylamine
  • Methanol