[Azithromycin as an adjuvant therapy in cryptogenic organizing pneumonia]

Rev Port Pneumol. Jul-Aug 2011;17(4):186-9. doi: 10.1016/j.rppneu.2011.03.010. Epub 2011 Jun 8.
[Article in Portuguese]

Abstract

There are literature data about the immunomodulatory properties of some macrolides in cryptogenic organizing pneumonia (COP) as an alternative to corticosteroids in mild disease or as adjuvant to standard therapy. A sixty-year-old female, with a controlled intrinsic asthma, presented with COP and recurrent respiratory exacerbations despite corticosteroid and immunossupressant therapy. Azithromycin (500mg, on alternate days) as an adjuvant to steroids was then started, with clinical and functional improvement and regression of lung infiltrates. Withdrawal of steroids was possible in one year, without evidence of relapse in the next six months. Azithromycin was maintained (three times per week) with no documentation of adverse side effects. This clinical case reinforces the potential role of macrolides anti-inflammatory properties in COP as corticosteroids adjuvant therapy.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / therapeutic use*
  • Chemotherapy, Adjuvant
  • Cryptogenic Organizing Pneumonia / drug therapy*
  • Female
  • Humans
  • Middle Aged

Substances

  • Anti-Bacterial Agents
  • Azithromycin