5-fluorouracil exposure during the period of conception: report on two cases

Am J Obstet Gynecol. 1990 Jul;163(1 Pt 1):76-7. doi: 10.1016/s0002-9378(11)90672-3.


Two patients who were administered topical vaginal 5-fluorouracil for human papilloma virus lesions became pregnant during treatment. The outcomes in both cases were healthy with normal developmental landmarks at 6 months of age. This experience highlights the potential for a positive outcome.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Female
  • Fertilization*
  • Fluorouracil / therapeutic use*
  • Humans
  • Infant, Newborn
  • Papillomaviridae
  • Pregnancy
  • Pregnancy Outcome
  • Tumor Virus Infections / drug therapy*


  • Fluorouracil