Multicentric evaluation of new commercial enzyme immunoassays for the detection of immunoglobulin M and total antibodies against hepatitis A virus

Clin Vaccine Immunol. 2011 Aug;18(8):1391-4. doi: 10.1128/CVI.00403-10. Epub 2011 Jun 8.


A multicentric clinical study was conducted on representative sera from 1,738 European and U.S. subjects for the evaluation of new anti-hepatitis A virus enzyme immunoassays from Bio-Rad Laboratories. Comparison with reference DiaSorin S.p.A. tests confirmed the good performance of Bio-Rad assays (99.85% and 99.47% overall agreement in detecting total antibodies and IgM, respectively).

Publication types

  • Comparative Study
  • Evaluation Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Laboratory Techniques / methods*
  • Hepatitis A / diagnosis*
  • Hepatitis A Antibodies / blood*
  • Hepatitis A virus / immunology*
  • Humans
  • Immunoenzyme Techniques / methods
  • Immunoglobulin M / blood*


  • Hepatitis A Antibodies
  • Immunoglobulin M