Monasnicotinates A-D, four new pyridine alkaloids from the fungal strain Monascus pilosus BCRC 38093

Molecules. 2011 Jun 7;16(6):4719-27. doi: 10.3390/molecules16064719.

Abstract

Four new pyridine derivatives, monasnicotinates A-D (1-4) were isolated from the red yeast rice of Monascus pilosus BCRC 38093. Their structures were elucidated on the basis of physicochemical evidence, in-depth NMR spectroscopic analysis, and high-resolution mass spectrometry. Their inhibitory effects on NO production was also evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology
  • Animals
  • Cell Survival / drug effects
  • Cells, Cultured
  • Macrophages / drug effects
  • Mice
  • Monascus / chemistry*
  • Nitric Oxide / biosynthesis
  • Nuclear Magnetic Resonance, Biomolecular
  • Pyridines / chemistry*
  • Pyridines / isolation & purification
  • Pyridines / pharmacology

Substances

  • Alkaloids
  • Pyridines
  • Nitric Oxide