Towards a functional understanding of protein N-terminal acetylation

PLoS Biol. 2011 May;9(5):e1001074. doi: 10.1371/journal.pbio.1001074. Epub 2011 May 31.


Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Protein Processing, Post-Translational
  • Protein Stability
  • Proteins / genetics
  • Proteins / metabolism*
  • Secretory Pathway
  • Signal Transduction


  • Proteins