9G DNAChip: a platform for the efficient detection of proteins

Chem Commun (Camb). 2011 Jul 21;47(27):7716-8. doi: 10.1039/c1cc12721g. Epub 2011 Jun 8.

Abstract

According to the proposed DAGON method, the CRP and PSA antigens with the concentrations of 1 pg ml(-1) to 10 pg ml(-1) range can be easily differentiated in the buffer matrix. Moreover, it is for the first time that the multiple antigens with the concentrations of 1 pg ml(-1) and 0.1 pg ml(-1) can be detected in the mixture of the proteins without an amplification technique.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Immobilized / immunology
  • C-Reactive Protein / analysis*
  • C-Reactive Protein / immunology
  • Humans
  • Male
  • Neoplasms / diagnosis
  • Oligonucleotide Array Sequence Analysis / methods*
  • Prostate-Specific Antigen / analysis*
  • Prostate-Specific Antigen / immunology
  • Sensitivity and Specificity

Substances

  • Antibodies, Immobilized
  • C-Reactive Protein
  • Prostate-Specific Antigen