First Report of the bla(OXA-58) Gene in a Clinical Isolate of Acinetobacter Baumannii in Rio De Janeiro, Brazil

Mem Inst Oswaldo Cruz. 2011 May;106(3):368-70. doi: 10.1590/s0074-02762011000300019.

Abstract

Carbapenemase production is an important mechanism of carbapenem resistance among nonfermentative Gram-negative isolates. This study aimed to report the detection of bla(OXA-58) gene in multiresistant clinical isolates of Acinetobacter baumannii recovered from inpatients in a public hospital. Polymerase chain reaction tests were performed to detect the bla(OXA-23-like), bla(OXA-24-like), bla(OXA-58-like) and bla(OXA-51-like) genes. The bla(OXA-58) and bla(OXA-23) genes were detected in one and three isolates, respectively. Sequencing of the bla(OXA-58-like) amplicon revealed 100% identity with the A. baumannii bla(OXA-58) gene listed in the GenBank database. This is the first report of an OXA-58-producing A. baumannii isolate in Rio de Janeiro, Brazil.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / enzymology
  • Acinetobacter baumannii / genetics*
  • Anti-Bacterial Agents / pharmacology
  • Disk Diffusion Antimicrobial Tests
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Polymerase Chain Reaction
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases
  • beta-lactamase OXA-58, Acinetobacter baumannii