B7-h1 and a mathematical model for cytotoxic T cell and tumor cell interaction

Bull Math Biol. 2012 Jan;74(1):91-102. doi: 10.1007/s11538-011-9665-1. Epub 2011 Jun 9.


The surface protein B7-H1, also called PD-L1 and CD274, is found on carcinomas of the lung, ovary, colon, and melanomas but not on most normal tissues. B7-H1 has been experimentally determined to be an antiapoptotic receptor on cancer cells, where B7-H1-positive cancer cells have been shown to be immune resistant, and in vitro experiments and mouse models have shown that B7-H1-negative tumor cells are significantly more susceptible to being repressed by the immune system. We derive a new mathematical model for studying the interaction between cytotoxic T cells and tumor cells as affected by B7-H1. By integrating experimental data into the model, we isolate the parameters that control the dynamics and obtain insights on the mechanisms that control apoptosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Apoptosis / immunology*
  • B7-H1 Antigen / immunology*
  • Cell Communication / immunology*
  • Humans
  • Models, Immunological*
  • Neoplasms / immunology*
  • Neoplasms / pathology
  • T-Lymphocytes, Cytotoxic / immunology*
  • T-Lymphocytes, Cytotoxic / pathology


  • B7-H1 Antigen