Chimeras of the Gs alpha subunit that had the NH2- or COOH-terminal sequence substituted for the corresponding region of the Gi alpha subunit constitutively activate adenylyl cyclase

Soc Gen Physiol Ser. 1990:45:117-24.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenylyl Cyclases / physiology*
  • Amino Acids / analysis
  • Animals
  • Cells, Cultured
  • Chimera / genetics*
  • Chimera / physiology
  • Cricetinae
  • Cricetulus
  • Cyclic AMP / metabolism
  • Cyclic AMP / physiology
  • Female
  • GTP-Binding Proteins / analysis
  • GTP-Binding Proteins / genetics*
  • GTP-Binding Proteins / physiology
  • Guanosine 5'-O-(3-Thiotriphosphate)* / analogs & derivatives*
  • Guanosine Triphosphate / analogs & derivatives*
  • Guanosine Triphosphate / analysis
  • Guanosine Triphosphate / genetics
  • Guanosine Triphosphate / physiology
  • Ovary / cytology
  • Ovary / metabolism
  • Ovary / physiology
  • Phenotype
  • Plasmids
  • Protein Kinases / metabolism
  • Simian virus 40 / genetics
  • Thionucleotides / analysis
  • Thionucleotides / genetics*
  • Thionucleotides / physiology
  • Transfection

Substances

  • Amino Acids
  • Thionucleotides
  • guanosine 5'-O-(1-thiotriphosphate)
  • Guanosine 5'-O-(3-Thiotriphosphate)
  • Guanosine Triphosphate
  • Cyclic AMP
  • Protein Kinases
  • GTP-Binding Proteins
  • Adenylyl Cyclases