Decreased expression of Bmal2 in patients with Parkinson's disease

Neurosci Lett. 2011 Jul 25;499(3):186-8. doi: 10.1016/j.neulet.2011.05.058. Epub 2011 May 30.

Abstract

Bmal1 is one of the central regulators of the clock machinery. Recently, we examined the expression profile of Bmal1 in total leukocytes for a 12h duration during the evening, overnight, and the morning, in subjects with Parkinson's disease (PD) and healthy controls. The results indicate that the expression of Bmal1 is significantly lower in PD patients versus control subjects. However, it is still unclear whether other key regulators of the clock machinery, especially Bmal2, the paralog of Bmal1, are also expressed differently in PD. To address this issue, the expression profiles of Bmal2, Clock, and Dec1 were examined in the same samples using real-time RT-PCR assay. The results show a difference in the expression pattern of Bmal2, but not Clock and Dec1. The expression of Bmal2 is significantly lower in PD at 21:00 h (p=0.005) and 00:00 h (p=0.025). These results together with our previous findings suggest that the molecular clock in total leukocytes is disturbed in PD patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ARNTL Transcription Factors / biosynthesis*
  • ARNTL Transcription Factors / blood
  • CLOCK Proteins / biosynthesis*
  • CLOCK Proteins / blood
  • Case-Control Studies
  • Circadian Rhythm / genetics*
  • Humans
  • Parkinson Disease / blood
  • Parkinson Disease / genetics*
  • Tumor Suppressor Proteins / biosynthesis*
  • Tumor Suppressor Proteins / blood

Substances

  • ARNTL Transcription Factors
  • ARNTL2 protein, human
  • DEC1 protein, human
  • Tumor Suppressor Proteins
  • CLOCK Proteins
  • CLOCK protein, human