Experience Dictates Stem Cell Fate in the Adult Hippocampus

Neuron. 2011 Jun 9;70(5):908-23. doi: 10.1016/j.neuron.2011.05.022.

Abstract

Adult hippocampal neurogenesis has been implicated in cognitive and emotional processes, as well as in response to antidepressant treatment. However, little is known about how the adult stem cell lineage contributes to hippocampal structure and function and how this process is modulated by the animal's experience. Here we perform an indelible lineage analysis and report that neural stem cells can produce expanding and persisting populations of not only neurons, but also stem cells in the adult hippocampus. Furthermore, the ratio of stem cells to neurons depends on experiences of the animal or the location of the stem cell. Surprisingly, social isolation facilitated accumulation of stem cells, but not neurons. These results show that neural stem cells accumulate in the adult hippocampus and that the stem cell-lineage relationship is under control of anatomic and experiential niches. Our findings suggest that, in the hippocampus, fate specification may act as a form of cellular plasticity for adapting to environmental changes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Antineoplastic Agents, Hormonal / pharmacology
  • Bacterial Proteins / genetics
  • Bromodeoxyuridine / metabolism
  • Cell Count / methods
  • Cell Death
  • Cranial Irradiation / methods
  • Environment
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / radiation effects
  • Hippocampus / cytology*
  • Hippocampus / drug effects
  • Hippocampus / radiation effects
  • Intermediate Filament Proteins / genetics
  • Luminescent Proteins / genetics
  • Mice
  • Mice, Transgenic
  • Models, Neurological
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Nestin
  • Neural Stem Cells / drug effects
  • Neural Stem Cells / physiology*
  • Neural Stem Cells / radiation effects
  • Neurogenesis / drug effects
  • Neurogenesis / physiology*
  • Neurogenesis / radiation effects
  • Social Isolation
  • Tamoxifen / pharmacology
  • Time Factors

Substances

  • Antineoplastic Agents, Hormonal
  • Bacterial Proteins
  • Intermediate Filament Proteins
  • Luminescent Proteins
  • Nerve Tissue Proteins
  • Nes protein, mouse
  • Nestin
  • yellow fluorescent protein, Bacteria
  • Tamoxifen
  • Bromodeoxyuridine