Effects of electromagnetic radiation produced by 3G mobile phones on rat brains: magnetic resonance spectroscopy, biochemical, and histopathological evaluation

Hum Exp Toxicol. 2012 Jun;31(6):557-64. doi: 10.1177/0960327111412092. Epub 2011 Jun 9.

Abstract

Objective: The effects of electromagnetic radiation (EMR) produced by a third-generation (3G) mobile phone (MP) on rat brain tissues were investigated in terms of magnetic resonance spectroscopy (MRS), biochemistry, and histopathological evaluations.

Methods: The rats were randomly assigned to two groups: Group 1 is composed of 3G-EMR-exposed rats (n = 9) and Group 2 is the control group (n = 9). The first group was subjected to EMR for 20 days. The control group was not exposed to EMR. Choline (Cho), creatinin (Cr), and N-acetylaspartate (NAA) levels were evaluated by MRS. Catalase (CAT) and glutathione peroxidase (GSH-Px) enzyme activities were measured by spectrophotometric method. Histopathological analyses were carried out to evaluate apoptosis in the brain tissues of both groups.

Results: In MRS, NAA/Cr, Cho/Cr, and NAA/Cho ratios were not significantly different between Groups 1 and 2. Neither the oxidative stress parameters, CAT and GSH-Px, nor the number of apoptotic cells were significantly different between Groups 1 and 2.

Conclusions: Usage of short-term 3G MP does not seem to have a harmful effect on rat brain tissue.

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Brain / anatomy & histology
  • Brain / metabolism
  • Brain / radiation effects*
  • Catalase / metabolism
  • Cell Phone*
  • Choline / metabolism
  • Creatinine / metabolism
  • Electromagnetic Radiation*
  • Glutathione Peroxidase / metabolism
  • Magnetic Resonance Spectroscopy
  • Male
  • Neurons / cytology
  • Neurons / radiation effects
  • Rats
  • Rats, Wistar

Substances

  • Aspartic Acid
  • N-acetylaspartate
  • Creatinine
  • Catalase
  • Glutathione Peroxidase
  • Choline