The blocking effects of omega-conotoxin on Ca current in bovine chromaffin cells

Neurosci Lett. 1990 Jun 22;114(1):63-8. doi: 10.1016/0304-3940(90)90429-d.


The effects of omega-conotoxin (omega-CgTX) on voltage-sensitive Ca currents (ICa) were studied in cultured bovine adrenal chromaffin cells. A maximal block of ICa of 40-50% was obtained with omega-CgTX in the microM range, and was independent of the holding potential. The onset of block was both concentration- and time-dependent. In bovine chromaffin cells, Ca channels, both sensitive and insensitive to omega-CgTX, appear to be present.

MeSH terms

  • Adrenal Medulla / drug effects
  • Adrenal Medulla / physiology*
  • Animals
  • Calcium Channel Blockers / pharmacology*
  • Calcium Channels / drug effects
  • Calcium Channels / physiology*
  • Cattle
  • Cells, Cultured
  • Evoked Potentials / drug effects
  • Kinetics
  • Membrane Potentials
  • Peptides, Cyclic / pharmacology*
  • omega-Conotoxin GVIA


  • Calcium Channel Blockers
  • Calcium Channels
  • Peptides, Cyclic
  • omega-Conotoxin GVIA