Regulation of Integrin Activation

Annu Rev Cell Dev Biol. 2011;27:321-45. doi: 10.1146/annurev-cellbio-100109-104104. Epub 2011 Jun 10.

Abstract

Regulation of cell-cell and cell-matrix interaction is essential for the normal physiology of metazoans and is important in many diseases. Integrin adhesion receptors can rapidly increase their affinity (integrin activation) in response to intracellular signaling events in a process termed inside-out signaling. The transmembrane domains of integrins and their interactions with the membrane are important in inside-out signaling. Moreover, integrin activation is tightly regulated by a complex network of signaling pathways. Here, we review recent progress in understanding how the membrane environment can, in cooperation with integrin-binding proteins, regulate integrin activation.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium-Binding Proteins / metabolism
  • Cell Adhesion / physiology
  • Cell Adhesion Molecules / metabolism
  • Contractile Proteins / metabolism
  • Cytoskeletal Proteins / metabolism
  • Filamins
  • Humans
  • Integrins / chemistry
  • Integrins / genetics
  • Integrins / physiology*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism
  • Microfilament Proteins / metabolism
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary
  • Protein-Serine-Threonine Kinases / metabolism
  • Sequence Alignment
  • Signal Transduction / physiology
  • Talin / metabolism
  • rap1 GTP-Binding Proteins / metabolism

Substances

  • CIB1 protein, human
  • Calcium-Binding Proteins
  • Cell Adhesion Molecules
  • Contractile Proteins
  • Cytoskeletal Proteins
  • FBLIM1 protein, human
  • Filamins
  • ITGB1BP1 protein, human
  • Integrins
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Microfilament Proteins
  • Talin
  • integrin-linked kinase
  • Protein-Serine-Threonine Kinases
  • rap1 GTP-Binding Proteins