A new cytokine receptor superfamily

Trends Biochem Sci. 1990 Jul;15(7):265-70. doi: 10.1016/0968-0004(90)90051-c.


The amino acid sequences of several, recently cloned cytokine receptors show significant homologies, primarily in their extracellular, ligand-binding domains. With one exception, their cognate cytokines mediate biological activities on a variety of hematopoietic cell types; thus we have designated the receptors as the hematopoietic receptor superfamily.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Factors / metabolism*
  • Cytokines
  • Humans
  • Molecular Sequence Data
  • Protein Conformation
  • Receptors, Cell Surface / classification
  • Receptors, Cell Surface / metabolism*
  • Receptors, Immunologic / classification
  • Receptors, Immunologic / metabolism*
  • Sequence Homology, Nucleic Acid


  • Biological Factors
  • Cytokines
  • Receptors, Cell Surface
  • Receptors, Immunologic