Rapid detection of "highly virulent" Group B Streptococcus ST-17 and emerging ST-1 clones by MALDI-TOF mass spectrometry

J Microbiol Methods. 2011 Aug;86(2):262-5. doi: 10.1016/j.mimet.2011.05.017. Epub 2011 Jun 2.


MALDI-TOF MS identified a 6250-Da protein specific to Sequence Type-1 (ST-1) strains and a 7625-Da protein specific to ST-17 strains when used for identification of Group B streptococci. The strains of these STs are major causes of meningitis and late-onset-disease in neonates. This rapid method of identification could thus be valuable in the evaluation of risk of neonatal diseases.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bacteriological Techniques / methods*
  • Female
  • Humans
  • Infant, Newborn
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
  • Streptococcal Infections / diagnosis*
  • Streptococcus agalactiae / chemistry
  • Streptococcus agalactiae / classification*
  • Streptococcus agalactiae / isolation & purification*