The human brain in a dish: the promise of iPSC-derived neurons

Cell. 2011 Jun 10;145(6):831-4. doi: 10.1016/j.cell.2011.05.034.


Induced pluripotent stem cell-derived neurons from patients promise to fill an important niche between studies in humans and model organisms in deciphering mechanisms and identifying therapeutic avenues for neurologic and psychiatric diseases. Recent work begins to tap this potential and also highlights challenges that must be overcome to be fully realized.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / cytology*
  • Brain Diseases / pathology
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Mental Disorders / pathology
  • Neurons / cytology*
  • Neurons / pathology