Lack of association between genetic variations in the KALRN region and ischemic stroke

Clin Biochem. 2011 Aug;44(12):1018-20. doi: 10.1016/j.clinbiochem.2011.05.025. Epub 2011 Jun 6.

Abstract

Objectives: To investigate whether KALRN gene variation is associated with ischemic stroke (IS).

Design and methods: Associations to overall IS and IS subtypes were investigated in SAHLSIS, which comprises 844 patients with IS and 668 controls.

Results: Associations between KALRN SNPs and overall IS and cardioembolic stroke were detected. Associations for overall IS were investigated in two additional Swedish samples, but could not be replicated.

Conclusion: KALRN gene variation is not associated with overall IS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain Ischemia / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease
  • Guanine Nucleotide Exchange Factors / genetics*
  • Humans
  • Male
  • Polymorphism, Single Nucleotide*
  • Protein Serine-Threonine Kinases / genetics*
  • Risk Factors
  • Stroke / genetics*
  • Sweden

Substances

  • Guanine Nucleotide Exchange Factors
  • KALRN protein, human
  • Protein Serine-Threonine Kinases