Seronegative spondyloarthritis

Best Pract Res Clin Rheumatol. 2010 Dec;24(6):747-56. doi: 10.1016/j.berh.2011.02.002.


Seronegative spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases with common clinical and aetiological features, including axial and peripheral inflammatory arthritis, enthesitis, extra-articular manifestations and a close link to the presence of the human leucocyte antigen (HLA)-B27 epitope. Ankylosing spondylitis is the most common of the SpA diseases, with prevalence in the Caucasian population ranging between 0.15% and 1.8%, generally higher in populations with a higher background prevalence of HLA-B27 positivity. Incidence has been estimated between 0.49 (Japan) and 10 (Norway) per 100,000. The prevalence of psoriatic arthritis ranges from 0.02% to 0.2%, and the incidence in the normal population is 7.2 per 100,000 per year. In patients with existing psoriasis, the prevalence of psoriatic arthritis rises to 6-42%. The prevalence of reactive arthritis is dependent on the background incidence of gastrointestinal or genitourinary infections; incidence has been described as up to 30-40 per 100,000. SpA symptoms are present in up to 50% of patients with inflammatory bowel disease.

Publication types

  • Review

MeSH terms

  • Arthritis, Psoriatic / epidemiology*
  • Arthritis, Psoriatic / immunology
  • Arthritis, Psoriatic / physiopathology
  • Female
  • HLA-B27 Antigen / analysis
  • Humans
  • Incidence
  • Inflammatory Bowel Diseases / epidemiology*
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / physiopathology
  • Male
  • Prevalence
  • Spondylitis, Ankylosing / epidemiology*
  • Spondylitis, Ankylosing / immunology
  • Spondylitis, Ankylosing / physiopathology


  • HLA-B27 Antigen