Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices

Eur J Pharmacol. 1990 Jun 8;181(3):323-6. doi: 10.1016/0014-2999(90)90099-r.


The effect of recombinant human interleukin 1-beta (IL-1 beta) on long-term potentiation (LTP) in the mossy fiber-CA3 pathway of mouse hippocampal slice preparations was investigated. IL-1 beta significantly inhibited LTP in concentrations as low as 2.9 pM (50 pg/ml). This effect of IL-1 beta was blocked by concurrent application of 100 nM Lys-D-Pro-Thr, a tripeptide analogue of IL-1 beta. This is the first evidence that IL-1 beta can regulate LTP of synaptic transmission in the hippocampus.

MeSH terms

  • Animals
  • Electric Stimulation
  • Hippocampus / cytology*
  • Hippocampus / drug effects
  • In Vitro Techniques
  • Interleukin-1 / pharmacology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Neural Pathways / drug effects*
  • Recombinant Proteins / pharmacology
  • Synapses / drug effects
  • Synaptic Transmission / drug effects


  • Interleukin-1
  • Recombinant Proteins