A genome-wide association study of DSM-IV cannabis dependence

Addict Biol. 2011 Jul;16(3):514-8. doi: 10.1111/j.1369-1600.2010.00255.x. Epub 2010 Nov 4.


Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Alleles
  • Chromosomes, Human, Pair 12 / genetics
  • Chromosomes, Human, Pair 17 / genetics
  • Diagnostic and Statistical Manual of Mental Disorders*
  • Female
  • Genetic Predisposition to Disease / genetics
  • Genome-Wide Association Study*
  • Genotype
  • Humans
  • Introns / genetics
  • Male
  • Marijuana Abuse / diagnosis
  • Marijuana Abuse / genetics*
  • Membrane Proteins / genetics
  • Phosphate-Binding Proteins
  • Polymorphism, Single Nucleotide / genetics
  • Sulfotransferases / genetics
  • Young Adult


  • ANKFY1 protein, human
  • Membrane Proteins
  • Phosphate-Binding Proteins
  • CHST11 protein, human
  • Sulfotransferases

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