Relations between plasma ox-LDL and carotid plaque among Chinese Han ethnic group

Neurol Res. 2011 Jun;33(5):460-6. doi: 10.1179/016164111X13007856083927.

Abstract

Objectives: To study the relationship between plasma oxidized low-density lipoprotein (ox-LDL) and carotid plaque, including plaque stability, of patients with acute ischemic stroke among Chinese Han ethnic group.

Methods: A total of 181 patients with acute ischemic stroke were recruited and enrolled. The subjects were divided into a carotid plaque group and a no-plaque group by carotid ultrasound. The stability of carotid atheromas was assessed by ultrasound echo density, and the carotid plaque group was further divided into a vulnerable plaque group and a stable plaque group based on the echo results.

Results: The study showed that the correlation between age [odds ratio (OR): 1.047; 95% confidence interval (CI): 1.014-1.082; P<0.01] and carotid plaque was significant. Plasma ox-LDL (OR: 1.020; 95%CI: 1.010-1.030; P<0.001) was also found to be significantly correlated with carotid plaque. Age was irrelevant to plaque stability (P = 0.0685). The ox-LDL of the vulnerable plaque group was found to be significantly higher than that of the stable plaque group (P = 0.015). By measuring the plasma ox-LDL in patients with ischemic stroke, the proportion under the receiver operating characteristic curve of vulnerable carotid plaques was 0.690 with a 95%CI of 0.613-0.767 (P<0.001). The point of cut-off was 94.5943, the sensitivity was 0.805, and the specificity was 0.505.

Conclusion: The plasma ox-LDL level and age are possible risk factors for carotid plaque among patients with ischemic stroke of the Chinese Han ethnic group. This study suggests that ox-LDL could be used as a biomarker in screening for vulnerable carotid plaque in clinical practice.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aging / blood
  • Asian Continental Ancestry Group / ethnology
  • Brain Ischemia / blood*
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / ethnology
  • Carotid Stenosis / blood*
  • Carotid Stenosis / diagnostic imaging
  • Carotid Stenosis / ethnology
  • China / epidemiology
  • Comorbidity
  • Female
  • Humans
  • Lipoproteins, LDL / blood*
  • Male
  • Middle Aged
  • Prospective Studies
  • Stroke / blood*
  • Stroke / diagnostic imaging
  • Stroke / ethnology
  • Ultrasonography

Substances

  • Lipoproteins, LDL
  • oxidized low density lipoprotein