Evolution: On a bender--BARs, ESCRTs, COPs, and Finally Getting Your Coat

J Cell Biol. 2011 Jun 13;193(6):963-72. doi: 10.1083/jcb.201102042.

Abstract

Tremendous variety in form and function is displayed among the intracellular membrane systems of different eukaryotes. Until recently, few clues existed as to how these internal membrane systems had originated and diversified. However, proteomic, structural, and comparative genomics studies together have revealed extensive similarities among many of the protein complexes used in controlling the morphology and trafficking of intracellular membranes. These new insights have had a profound impact on our understanding of the evolutionary origins of the internal architecture of the eukaryotic cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Biological Transport / physiology
  • Coat Protein Complex I / chemistry
  • Coat Protein Complex I / genetics
  • Coat Protein Complex I / metabolism*
  • Endosomal Sorting Complexes Required for Transport / chemistry
  • Endosomal Sorting Complexes Required for Transport / genetics
  • Endosomal Sorting Complexes Required for Transport / metabolism*
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism*
  • Intracellular Membranes / chemistry
  • Intracellular Membranes / metabolism*

Substances

  • Coat Protein Complex I
  • Endosomal Sorting Complexes Required for Transport