The Pre-diabetes Risk Education and Physical Activity Recommendation and Encouragement (PREPARE) programme study: are improvements in glucose regulation sustained at 2 years?

Diabet Med. 2011 Oct;28(10):1268-71. doi: 10.1111/j.1464-5491.2011.03357.x.


Objective: To determine whether improvements in glucose regulation following the PREPARE structured education programme were sustained at 24 months.

Patients and methods: Ninety-eight overweight or obese individuals with impaired glucose tolerance were randomized to receive: (1) advice leaflet, (2) 3-h structured education programme aimed at promoting physical activity, (iii) 3-h structured education with personalized pedometer use. The primary outcome was change in 2-h post-challenge plasma glucose.

Results: Seventy-three (74%) individuals were included for analysis at 24 months; age 65 ± 8 years, BMI 29.3 ± 4.8 kg/m(2), South Asian ethnicity 21%. A statistically significant reduction in 2-h glucose of -1.6 mmol/l (-0.4 to -2.7) was seen in the education-with-pedometer group compared with the control group. There is no significant difference in the education-only group.

Conclusion: Improvements in glucose regulation following a pragmatic group-based structured education with pedometer use were sustained at 24 months.

Trial registration: NCT00566319.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / prevention & control
  • Diabetes Mellitus, Type 2 / psychology*
  • Female
  • Follow-Up Studies
  • Glucose Intolerance / complications
  • Glucose Intolerance / physiopathology
  • Glucose Intolerance / psychology*
  • Health Knowledge, Attitudes, Practice
  • Health Promotion*
  • Humans
  • Male
  • Middle Aged
  • Motor Activity
  • Obesity / complications
  • Obesity / physiopathology
  • Obesity / psychology*
  • Patient Education as Topic*
  • Prediabetic State / psychology*
  • Waist Circumference
  • Walking

Associated data