Neurological complications of vaccination with outer surface protein A (OspA)

Int J Risk Saf Med. 2011;23(2):89-96. doi: 10.3233/JRS-2011-0527.

Abstract

A wide range of neurological complications have been reported via the medical literature and the VAERS system after vaccination with recombinant outer surface protein A (OspA) of Borrelia. To explore this issue, 24 patients reporting neurological adverse events (AE) after vaccination with Lymerix, out of a group of 94 patients reporting adverse events after Lymerix vaccination, were examined for causation. Five reports of cerebral ischemia, two transient Ischemic attacks, five demyelinating events, two optic neuritis, two reports of transverse myelitis, and one non-specific demyelinating condition are evaluated in this paper. Caution is raised on not actively looking for neurologic AE, and for not considering causation when the incidence rate is too low to raise a calculable difference to natural occurence.

MeSH terms

  • Adverse Drug Reaction Reporting Systems
  • Antigens, Surface / administration & dosage
  • Antigens, Surface / adverse effects*
  • Bacterial Outer Membrane Proteins / administration & dosage
  • Bacterial Outer Membrane Proteins / adverse effects*
  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / adverse effects*
  • Borrelia burgdorferi / immunology*
  • Brain Ischemia / etiology
  • Demyelinating Diseases / etiology
  • Female
  • Humans
  • Lipoproteins / administration & dosage
  • Lipoproteins / adverse effects*
  • Lyme Disease / epidemiology
  • Lyme Disease / prevention & control*
  • Male
  • Middle Aged
  • Nervous System / drug effects*
  • Optic Neuritis / etiology
  • Risk Assessment
  • United States / epidemiology
  • Vaccination / adverse effects*
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / adverse effects

Substances

  • Antigens, Surface
  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • Lipoproteins
  • OspA protein
  • Vaccines, Synthetic