Multicenter evaluation of an interdisciplinary 52-week weight loss program for obesity with regard to body weight, comorbidities and quality of life--a prospective study

Int J Obes (Lond). 2012 Apr;36(4):614-24. doi: 10.1038/ijo.2011.107. Epub 2011 Jun 14.

Abstract

Objectives: To determine the effectiveness of a structured multidisciplinary non-surgical obesity therapy program on the basis of a temporary low-calorie-diet for 12 weeks, and additional intervention modules to enhance nutritional education, to increase physical activity and to modify eating behavior.

Design: Prospective multicenter observational study in obese individuals undergoing a medically supervised outpatient-based 52-week treatment in 37 centers in Germany.

Subjects: A total of 8296 participants with a body mass index (BMI) of >30 kg m(-2) included within 8.5 years.

Measurements: Main outcome measures were body weight loss, waist circumference (WC), blood pressure, quality of life and adverse events.

Results: In females, initial body weight was reduced after the 1-year-intervention by 19.6 kg (95% confidence intervals 19.2-19.9 kg) and in males by 26.0 kg (25.2-26.8) according to per protocol analysis of 4850 individuals. Intention-to-treat (ITT) analysis revealed a weight reduction of 15.2 kg (14.9-15.6) in females and 19.4 kg (18.7-20.1) in males. Overall, the intervention resulted in mean reduction in WC of 11 cm; it reduced the prevalence of the metabolic syndrome by 50% and the frequency of hypertension from 47 to 29% of all participants (ITT, all P<0.001). The beneficial effects could be documented for up to 3 years and comprised significant improvement of health-related quality of life. The incidence of adverse effects was low; the only event repeatedly observed and possibly related to either the intervention or the underlying disease was biliary disorders.

Conclusion: The present non-surgical intervention program is a highly effective treatment of obesity grades I-III and obesity-related diseases, and therefore, could be a valuable basis for future weight maintenance strategies required for sustained success.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Body Weight*
  • Caloric Restriction* / methods
  • Comorbidity
  • Female
  • Germany / epidemiology
  • Humans
  • Hypertension / diet therapy
  • Hypertension / epidemiology*
  • Interdisciplinary Communication*
  • Male
  • Metabolic Syndrome / diet therapy
  • Metabolic Syndrome / epidemiology*
  • Middle Aged
  • Obesity / diet therapy
  • Obesity / epidemiology*
  • Prospective Studies
  • Quality of Life*
  • Waist Circumference
  • Weight Reduction Programs / methods*
  • Young Adult