Acridine and acridinones: old and new structures with antimalarial activity

Open Med Chem J. 2011;5:11-20. doi: 10.2174/1874104501105010011. Epub 2011 Mar 9.

Abstract

Since emergence of chloroquine-resistant Plasmodium falciparum and reports of parasite resistance to alternative drugs, there has been renewed interest in the antimalarial activity of acridines and their congeners, the acridinones. This article presents literature compilation of natural acridinone alkaloids and synthetic 9-substituted acridines, acridinediones, haloalcoxyacridinones and 10-N-substituted acridinones with antimalarial activity. The review also provides an outlook to antimalarial modes of action of some described compounds.

Keywords: Malaria; Plasmodium falciparum; acridine; acridinone; acridone; anti-malarial activity.; protozoa.