Presynaptic mechanism for long-term potentiation in the hippocampus

Nature. 1990 Aug 23;346(6286):724-9. doi: 10.1038/346724a0.


Experiments analysing the statistical properties of synaptic transmission, before and after the induction of long-term potentiation (LTP), suggest that expression of LTP largely arises in a presynaptic mechanism--an increased probability of transmitter release.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cells, Cultured
  • Evoked Potentials
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Kinetics
  • Neurons / physiology
  • Rats
  • Synapses / physiology*
  • Synaptic Transmission*